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And we must not overlook the truth that the persistent modifications are pushed by nicotine itself, not other elements of tobacco smoke; clearly this argues against the suitability of NRT for smoking cessation in this age group." What appears to alarm Slotkin most is the fact that fetal nicotine harms, including dependency susceptibility, are compounded by adolescent nicotine harm. As Slotkin places it, "the interplay of prenatal and adolescent nicotine goes beyond the difficulty of increased drug intake.

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